昌鸣先，女，博士，博士生导师，中国科学院水生生物研究所研究员。

个人技术特长

抗病原体感染的分子机制，免疫系统基因的可变剪接及其功能，病原体-宿主的相互作用。

成果荣誉展示

代表论著：

1. Chang MX, Zou J, Nie P, Huang B, Yu Z, Collet B, Secombes CJ. Intracellular interferons in fish: A unique means to combat viral infection. PLOS Pathogens. 2013, 9(11):e**.

2. Chang M, Collet B, Nie P, Lester K, Campbell S, Secombes CJ, Zou J. Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in rainbow trout (Oncorhynchus mykiss). J Virol. 2011,85(16):8403-12.

3. Chang MX, Wang T, Nie P, Zou J, Secombes CJ. Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains. Fish Shellfish Immunol. 2011,30(1):118-27.

4. Chang MX, Chen WQ, Nie P. Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappaB signalling. Dev Comp Immunol. 2010;34:1-13.

5. Chang MX, Wang YP, Nie P. Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways. Fish Shellfish Immunol. 2009;26:264-74.

6. Chang MX, Nie P, Collet B, Secombes CJ, Zou J. Identification of an additional two-cysteine containing type I interferon in rainbow trout Oncorhynchus mykiss provides evidence of a major gene duplication event within this gene family in teleosts. Immunogenetics 2009;61:315-25.

7. Chang MX, Nie P. RNAi suppression of zebrafish peptidoglycan recognition protein 6 (zfPGRP6) mediated differentially expressed genes involved in Toll-like receptor signaling pathway and caused increased susceptibility to Flavobacterium columnare. Vet Immunol Immunopathol. 2008;124:295-301.

8. Chang MX, Nie P, Wei LL. Short and long peptidoglycan recognition proteins (PGRPs) in zebrafish, with findings of multiple PGRP homologs in teleost fish. Mol Immunol. 2007;44(11):3005-23.

9. Chang MX, Sun BJ, Nie P. The first non-mammalian CXCR3 in a teleost fish: gene and expression in blood cells and central nervous system in the grass carp (Ctenopharyngodon idella). Mol Immunol. 2007;44(6):1123-34.

10. Zou PF, Chang MX*, Li Y, Zhang SH, Fu JP, Chen SN, Nie P*. Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. Fish Shellfish Immunol. 2015;43(1):13-24. (*示通讯作者)

11. Zou PF, Chang MX*, Xue NN, Liu XQ, Li JH, Fu JP, Chen SN, Nie P*. Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant. Immunology. 2014;141(2):192-202.

12. Li JH, Chang MX*, Xue NN, Nie P*. Functional characterization of a short peptidoglycan recognition protein, PGRP5 in grass carp Ctenopharyngodon idella. Fish Shellfish Immunol. 2013;35(2):221-30.

13. Chen WQ, Hu YW, Zou PF, Ren SS, Nie P, Chang MX*. MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. Dev Comp Immunol. 2015;49(1):19-30.

14. Yu ZL, Li JH, Xue NN, Nie P, Chang MX*. Expression and functional characterization of PGRP6 splice variants in grass carp Ctenopharyngodon idella. Dev Comp Immunol. 2014;47(2):264-74.

15. Hu YW, Yu ZL, Xue NN, Nie P, Chang MX*. Expression and protective role of two novel NACHT-containing proteins in pathogen infection. Dev Comp Immunol. 2014;46(2):323-32.

16. Li JH, Yu ZL, Xue NN, Zou PF, Hu JY, Nie P, Chang MX*. Molecular cloning and functional characterization of peptidoglycan recognition protein 6 in grass carp Ctenopharyngodon idella. Dev Comp Immunol. 2014;42(2):244-55.

17. Wang G, Li J, Zou P, Xie H, Huang B, Nie P, Chang M*. Expression pattern, promoter activity and bactericidal property of β-defensin from the mandarin fish Siniperca chuatsi. Fish Shellfish Immunol. 2012;33(3):522-31.

18. Guo HZ, Zou PF, Fu JP, Guo Z, Zhu BK, Nie P, Chang MX*. Characterization of two C-type lectin-like domain (CTLD)-containing proteins from the cDNA library of Chinese mitten crab Eriocheir sinensis. Fish Shellfish Immunol. 2011,30(2):515-24.

科研项目

（ 1 ） 鱼类模式识别受体在信号传导通路及免疫反应中的作用, 主持, 国家级, 2009-01–2012-12；

（ 2 ） 淡水池塘集约化养殖的基础科学问题研究, 参与, 国家级, 2009-01–2013-12；

（ 3 ） 草鱼肽聚糖识别蛋白不同剪接异构体在抗菌及炎症反应中的作用, 主持, 国家级, 2012-01–2015-12；

（ 4 ） 斑马鱼胞内模式识别受体NLRC5在抗感染中的作用及其机制, 主持, 国家级, 2014-01–2017-12。