朴顺福博士：韩国釜山国立大学药科大学药学博士，韩国国家BK21项目博士后、新加坡新星科技研究局分子和细胞生物学研究所博士后。

现担任山东维真生物科技有限公司特聘专家。

主要研究成果：在过去八年的科研时间里，共发表了20多篇SCI的学术论文。 在全球首次解析了与免疫有关的clip-domain 蛋白的结构和功能，在欧美相关领域引起强烈反响，并广为引用。首次用最具说服力的数据解析了wnt/beta-catenin（肿瘤细胞信号传导）信号传导中上游信号传导的关系，在全世界引起轰动，被誉为该领域的“埃菲尔铁塔”。除此以外还研发了对乙型糖尿病以及老年痴呆有治疗效果的多肽，申请并获得了发明专利。

发表论文：

1. Piao S, Kim D, Won Park J, Leul Lee B, Ha NC.

Overexpression and preliminary X-ray crystallographic analysis of prophenoloxidase activating factor II, a clip domain family of serine proteases.

Biochim Biophys Acta. 2005 Aug 31;1752(1):103-6. (IF: 3)

2. Piao S, Song YL, Kim JH, Park SY, Park JW, Lee BL, Oh BH, Ha NC.

Crystalstructure of a clip-domain serine protease and functional roles of the clip domains.

EMBO J. 2005 Dec 21;24(24):4404-14. (IF: 9.8)

3. Piao S, Jung JY, Park JW, Lee J, Lee BL, Ha NC.

Preliminary X-ray crystallographic analysis of the catalytic domain of prophenoloxidase activating factor-I.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 1;62(Pt 8):771-3.

4. Piao S, Kim S, Kim JH, Park JW, Lee BL, Ha NC.

Crystalstructure of the serine protease domain of prophenoloxidase activating factor-I.

J Biol Chem. 2007 Apr 6;282(14):10783-91. (IF: 4.6)

5. Piao S, Xu Y, Ha NC.

Crystallization and preliminary X-ray crystallographic analysis of MacA from Actinobacillus actinomycetemcomitans.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 May 1;64(Pt 5):391-3.

6. Piao S, Lee SH, Kim H, Yum S, Stamos JL, Xu Y, Lee SJ, Lee J, Oh S, Han JK, Park BJ, Weis WI, Ha NC.

Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling.

PLoS ONE. 2008;3(12):e4046. Epub 2008 Dec 24. (IF: 4)

7. Piao S, Jin XL, Yun BY, Kim N, Cho HS, Fukuda M, Lee H, Ha NC.

Crystal structure and functional insight of HP0420-homolog from Helicobacter felis.

Biochem Biophys Res Commun. 2010 Apr 16;394(4):962-5. (IF: 2.4)

8. Piao S, Lee SJ, Xu Y, Gwak J, Oh S, Park BJ, Ha NC.

CK1ε targets Cdc25A for ubiquitin-mediated proteolysis under normal conditions and in response to checkpoint activation.

Cell Cycle. 2011 Feb 1;10(3):531-7. Epub 2011 Feb 1. (IF: 5)

9. Park JW, Je BR, Piao S, Inamura S, Fujimoto Y, Fukase K, Kusumoto S, Söderhäll K, Ha NC, Lee BL.

A synthetic peptidoglycan fragment as a competitive inhibitor of the melanization cascade.

J Biol Chem. 2006 Mar 24;281(12):7747-55.

10. Yum S, Xu Y, Piao S, Sim SH, Kim HM, Jo WS, Kim KJ, Kweon HS, Jeong MH, Jeon H, Lee K, Ha NC.

Crystal Structure of the Periplasmic Component of a Tripartite Macrolide-Specific Efflux Pump.

J Mol Biol. 2009 Apr 17;387(5):1286-97.

11. Yum S, Lee SJ, Piao S, Xu Y, Jung J, Jung Y, Oh S, Lee J, Park BJ, Ha NC.

The role of the Ser/Thr cluster in the phosphorylation of PPPSP motifs in Wnt coreceptors.

Biochem Biophys Res Commun. 2009 Apr 10;381(3):345-9.

12.NamKH, Xu Y, Piao S, Priyadarshi A, Lee EH, Kim HY, Jeon YH, Ha NC,HwangKY.

Crystal structure of bacterioferritin from Rhodobacter sphaeroides.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):990-4. 

13. Park SH, Piao S, Kwon HM, Kim EH, Lee BL, Ha NC.

Crystallization and preliminary X-ray crystallographic analysis of a highly specific serpin from the beetle Tenebrio molitor.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Feb 1;66(Pt 2):198-200.

14. Xu Y, Sim SH, Song S, Piao S, Kim HM, Jin XL, Lee K, Ha NC.

The tip region of the MacA alpha-hairpin is important for the binding to TolC to the Escherichia coli MacAB-TolC pump.

Biochem Biophys Res Commun. 2010 Apr 16;394(4):962-5. 

15. Xu Y, Lee SH, Kim HS, Kim NH, Piao S, Park SH, Jung YS, Yook JI, Park BJ, Ha NC.

Role of CK1 in GSK3beta-mediated phosphorylation and degradation of Snail.

Oncogene. 2010 May 27;29(21):3124-33.

16. Xu Y, Sim SH, Song S, Piao S, Kim HM, Jin XL, Lee K, Ha NC.

The tip region of the MacA alpha-hairpin is important for the binding to TolC to the Escherichia coli MacAB-TolC pump.

Biochem Biophys Res Commun. 2010 Apr 16;394(4):962-5. 

17. Kim HM, Xu Y, Lee M, Piao S, Sim SH, Ha NC, Lee K.

Functional interrelationships between the AcrA hairpin tip region and the TolC aperture tip region for the formation of bacterial tripartite efflux pump AcrAB-TolC.

J Bacteriol. 2010 Sep;192(17):4498-503.

18. Park SH, Jiang R, Piao S, Zang B, Kim EH, Kwon HM, Jin XJ, Lee BL, Ha NC.

Structural and functional characterization of a highly specific serpin in the insect innate immunity.

J Biol Chem. 2011 Jan 14;286(2):1567-75. Epub 2010 Nov 3.

19. Yun BY, Xu Y, Piao S, Kim N, Yoon JH, Cho HS, Lee K, Ha NC.

Periplasmic domain of CusA in an Escherichia coli Cu+/Ag+ transporter has metal binding sites.

J Microbiol. 2010 Dec;48(6):829-35. Epub 2011 Jan 9.

20. Xu Y, Song S, Moeller A, Kim N, Piao S, Sim SH, Kang M, Yu W, Cho HS, Chang I, Lee K, Ha NC.

Functional implications of an intermeshing cogwheel-like interaction between TolC and MacA in the action of macrolide-specific efflux pump MacAB-TolC.

J Biol Chem. 2011 Apr 15;286(15):13541-9. Epub 2011 Feb 16.

21. Yun BY, Piao S, Kim YG, Moon HR, Choi EJ, Kim YO,NamBH, Lee SJ, Ha NC.

Crystallization and preliminary X-ray crystallographic analysis of Salmonella Typhimurium CueP.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jun 1;67(Pt 6):675-7. Epub 2011 May 25.

22. Gong EJ, Park HR, Kim ME, Piao S, Lee E, Jo DG, Chung HY, Ha NC, Mattson MP, Lee J.

Morin attenuates tau hyperphosphorylation by inhibiting GSK3β.

Neurobiol Dis. 2011 Nov;44(2):223-30. doi: 10.1016/j.nbd.2011.07.005. Epub 2011 Jul 18.

23. Yun BY, Jun SY, Kim NA, Yoon BY, Piao S, Park SH, Jeong SH, Lee H, Ha NC.

Crystal structure and thermostability of a putative α-glucosidase from Thermotoga neapolitana.

Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):92-8. Epub 2011 Nov 10.

24. Lai T, Cho H, Liu Z, Bowler MW, Piao S, Parker R, Kim YK, Song H.

Structural Basis of the PNRC2-Mediated Link between mRNA Surveillance and Decapping.

Structure. 2012 Dec 5;20(12):2025-37. doi: 10.1016/j.str.2012.09.009. Epub 2012 Oct 18.

25. Kim JS, Piao S, Lee E, Yoon BY, Moon HY, Lee J, Jung Y, Ha NC

Development of Akt-activated GSK3beta inhibitory peptide.

Biochem Biophys Res Commun. 2013 May 17;434(4):735-9. doi: 10.1016/j.bbrc.2013.03.103. Epub 2013 Apr 10.