伊万(Ivan Jakovlic)

生物信息学分析行家

01

可转化技术

组学

  • 生物信息学分析
  • 组学数据解读
  • 生物进化分析

02

个人简介

个人技术特长

综合利用生物学,计算机科学和信息技术而揭示大量而复杂的生物数据所赋有的生物学奥秘,在生物进化分析上建立了一套自己的分析研究体系,居于世界领先水平,可针对性的开发相关软件或程序。

可提供对转录组、蛋白组、代谢组数据的解读筛选,帮助客户更快聚焦目的基因,探索生物学奥秘。此外还提供常规的DNA分析,RNA分析,蛋白分析,进化分析和绘图等辅助性分析。

语言能力
英语 (精通), 汉语 (中级), 德语 (基层), 克罗地亚语 (母语)

成果荣誉展示

代表论文:

1. Chen J, Ni P, Li X, Han J, JakovlićI, Zhang C, et al. Population size may shape the accumulation of functional mutations following domestication. BMC Evol Biol. 2018;18: 4. doi:10.1186/s12862-018-1120-6

2. Jiang H, Hu Y, Wei X, Xiao X, JakovlićI, Liu X, et al. Chemotactic effect ofβ-defensin 1 on macrophages in Megalobrama amblycephala. Fish Shellfish Immunol. 2018;74. doi:10.1016/j.fsi.2017.12.016ondrial genome of parasitic nematode Camallanus cotti: extreme discontinuity in the rate of mitogenomic architecture evolution within the Chromadorea class. BMC Genomics. 2017;18: 840. doi:10.1186/s12864-017-4237-x

4. Prathomya P, Prisingkorn W, JakovlićI, Deng F-YF-Y, Zhao Y-H, Wang W-MW-M. 1H NMR-based metabolomics approach reveals metabolic alterations in response to dietary imbalances in Megalobrama amblycephala. Metabolomics. 2017;13: 17. doi:10.1007/s11306-016-1158-7

5. Prisingkorn W, Prathomya P, JakovlićI, Liu H, Zhao Y-HH, Wang W-MM. Transcriptomics, metabolomics and histology indicate that high-carbohydrate diet negatively affects the liver health of blunt snout bream (Megalobrama amblycephala). BMC Genomics. 2017;18: 856. doi:10.1186/s12864-017-4246-9

6. Zhang D, Zou H, Wu SG, Li M, JakovlićI, Zhang J, et al. Sequencing of the complete mitochondrial genome of a fish-parasitic flatworm Paratetraonchoides inermis (Platyhelminthes: Monogenea): tRNA gene arrangement reshuffling and implications for phylogeny. Parasit Vectors. 2017;10: 462. doi:10.1186/s13071-017-2404-1

7. Zhang D, Zou H, Wu SG, Li M, JakovlićI, Zhang J, et al. Sequencing, characterization and phylogenomics of the complete mitochondrial genome of Dactylogyrus lamellatus (Monogenea: Dactylogyridae). J Helminthol. 2017; 1–12. doi:10.1017/S0022149X17000578

8. Liu F-F, Li Y-P, JakovlićI, Yuan X-Q. Tandem duplication of two tRNA genes in the mitochondrial genome of Tagiades vajuna (Lepidoptera: Hesperiidae). EJE. 2017;114: 407–415. doi:10.14411/eje.2017.052

9. Wang J-G, Zhang D, JakovlićI, Wang W-MW-M, Gui J, Hwang D-F. Sequencing of the complete mitochondrial genomes of eight freshwater snail species exposes pervasive paraphyly within the Viviparidae family (Caenogastropoda). PLoS One. Public Library of Science (PLoS); 2017;12: e0181699. doi:10.1371/journal.pone.0181699

10. Hao YT, Wu SG, Xiong F, Tran NT, JakovlićI, Zou H, et al. Succession and fermentation products of grass carp (Ctenopharyngodon idellus) hindgut microbiota in response to an extreme dietary shift. Front Microbiol. 2017;8. doi:10.3389/fmicb.2017.01585

11. Hao YT, Wu SG, JakovlićI, Zou H, Li WX, Wang GT. Impacts of diet on hindgut microbiota and short-chain fatty acids in grass carp (Ctenopharyngodon idellus). Aquac Res. 2017;48: 5595–5605. doi:10.1111/are.13381

12. Wang T, Gao X, JakovlićI, Liu H-ZH-Z. Life tables and elasticity analyses of Yangtze River fish species with implications for conservation and management. Rev Fish Biol Fish. 2017;27. doi:10.1007/s11160-016-9464-8

13. Tran NT, JakovlićI, Wang W-M. The first report of diablo in Megalobrama amblycephala: characterization, phylogenetic analysis, functional annotation and expression. J Genet. 2017;96: 613–623. doi:10.1007/s12041-017-0816-5

14. Zhan F-B, Liu H, Lai R-F, JakovlićI, Wang W-M. Expression and functional characterization of interferon regulatory factors (irf2, irf7 and irf9) in the blunt snout bream (Megalobrama amblycephala). Dev Comp Immunol. 2017;67. doi:10.1016/j.dci.2016.09.014

15. JakovlićI, Liu H, Wang W-M. Identification, origin and evidence for retained functionality of two IκBαparalogs in Megalobrama amblycephala. Dev Comp Immunol. 2016;62: 89–96. doi:10.1016/j.dci.2016.05.002

16. JakovlićI, Wang W-M. Expression of Hox paralog group 13 genes in adult and developing Megalobrama amblycephala. Gene Expr Patterns. 2016;21: 63–68. doi:10.1016/j.gep.2016.07.001

17. Wang T, JakovlićI, Huang D, Wang J-G, Shen J-Z. Reproductive strategy of the invasive sharpbelly, Hemiculter leucisculus (Basilewsky 1855), in Erhai Lake, China. J Appl Ichthyol. 2016;32. doi:10.1111/jai.13001

18. Lai R, Liu H, JakovlićI, Zhan F, Wei J, Yang P, et al. Molecular cloning and expression of toll-like receptor 4 (tlr4) in the blunt snout bream (Megalobrama amblycephala). Dev Comp Immunol. 2016;59: 63–76. doi:10.1016/j.dci.2016.01.009

19. Zhan F-B, Liu H, Lai R-F, JakovlićI, Wang W-B, Wang W-M. Molecular identification and functional characterisation of the interferon regulatory factor 1 in the blunt snout bream (Megalobrama amblycephala). Fish Shellfish Immunol. 2016;54: 456–465. doi:10.1016/j.fsi.2016.05.002

20. Lai R-F, JakovlićI, Liu H, Zhan F-B, Wei J, Wang W-M. Molecular characterization and immunological response analysis of toll-like receptors from the blunt snout bream (Megalobrama amblycephala). Dev Comp Immunol. 2017;67. doi:10.1016/j.dci.2016.09.005

21. Lai RF, JakovlićI, Liu H, Wei J, Zhan FB, Yang PH, et al. Characterization and expression of Megalobrama amblycephala toll-like receptor 22 involved in the response to Aeromonas hydrophila. J Fish Biol. 2017;90: 803–818. doi:10.1111/jfb.13199

22. JakovlićI, Piria M,Šprem N, TomljanovićT, MatulićD, Treer T. Distribution, abundance and condition of invasive Ponto-Caspian gobies Ponticola kessleri (Günther, 1861), Neogobius fluviatilis (Pallas, 1814), and Neogobius melanostomus (Pallas, 1814) in the Sava River basin, Croatia. J Appl Ichthyol. 2015;31: n/a-n/a. doi:10.1111/jai.12803

23. Piria M, JakšićG, JakovlićI, Treer T. Dietary habits of invasive Ponto-Caspian gobies in the Croatian part of the Danube River basin and their potential impact on benthic fish communities. Sci Total Environ. 2015; doi:10.1016/j.scitotenv.2015.05.125

24. Wang T, Gao X, Wang J, JakovlićI, Dan S-G, Liu H-Z. Life history traits and implications for conservation of rock carp Procypris rabaudi Tchang, an endemic fish in the upper Yangtze River, China. Fish Sci. 2015;81: 515–523. doi:10.1007/s12562-015-0872-9

25. Tran N, Liu H, JakovlićI, Wang W-M. Blunt Snout Bream (Megalobrama amblycephala) MyD88 and TRAF6: Characterisation, Comparative Homology Modelling and Expression. Int J Mol Sci. 2015;16: 7077–7097. doi:10.3390/ijms16047077

26. Tran NT, JakovlićI, Wang W-M. In silico characterisation, homology modelling and structure-based functional annotation of blunt snout bream (Megalobrama amblycephala) Hsp70 and Hsc70 proteins. J Anim Sci Technol. 2015;57: 44. doi:10.1186/s40781-015-0077-x

03

工作学习经历

工作经历

2015 - Present

转导精进(武汉)生物技术有限公司

留学生及海外市场负责人,中国,武汉

2013 - 2015

华中农业大学

水产学院,博士后,中国,武汉

2012-2013

Guildford, UK

Ecologist/Field Surveyor

2011-2012

University of Agriculture, Zagreb, Croatia

Research Fellow on the project “Distribution, biology and ecological impacts of invasive gobies in Croatia”

学习经历

1995-2001

University of Zagreb, Croatia

Animal Husbandry, Faculty of Agriculture,学士

2004-2011

中国科学院水生生物研究所

鱼类遗传学, 博士,中国,武汉

聚生物

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